Furuya S, Kumamoto Y, Ikegaki S
Arch Androl. 1980 Dec;5(4):361-7. doi: 10.3109/01485018008987007.
Immature-type Sertoli cells in the testes of idiopathic hypogonadotropic eunuchoidism (17-30 years of age) had no specialized junctions. The specialized Sertoli junctions that blocked the penetration of lanthanum were formed six months to two years after hCG treatment (5000 IU twice a week) in patients of hypogonadotropic eunuchoidism. In two patients with postpubertal pituitary failure (one had a ectopic pinealoma, irradiated one year ago, and the other had a pituitary adenoma, hypophysectomized four years ago), the ultrastructural integrity of these Sertoli junctions was maintained. Therefore, it may be suggested that the development of the blood-testis barrier is dependent on gonadotropins, but the maintenance of the blood-testis barrier is not.
特发性低促性腺激素性类无睾症（17 - 30岁）患者睾丸中的未成熟型支持细胞没有特化连接。在低促性腺激素性类无睾症患者中，经人绒毛膜促性腺激素（hCG）治疗（每周两次，每次5000国际单位）后6个月至2年，形成了能阻止镧穿透的特化支持细胞连接。在两名青春期后垂体功能减退患者中（一名患者一年前因异位松果体瘤接受了放疗，另一名患者四年前因垂体腺瘤接受了垂体切除术），这些支持细胞连接的超微结构完整性得以维持。因此，可能提示血睾屏障的发育依赖于促性腺激素，但血睾屏障的维持并非如此。
