Meola G, Manfredi L, Scarpini E, Dall'Oglio P, Mariani C, Scarlato G
Basic Appl Histochem. 1980;24(3):193-202.
Two cases of pentazocine-induced neuromuscular syndrome in addicted patients are reported. Histochemical and histographic analysis of muscle biopsies performed in areas distant from the site of injection, disclosed type II muscle fibre atrophy. In order to clarify the pentazocine myotoxic mechanism, a tissue culture study was performed and the effects of the drug on the extent of myogenesis in human foetal muscle cultures were assayed. The tissue culture studies showed: 1 a complete block of myogenesis in pentazocine-treated human foetal muscle cultures and 2. a delayed fusion process when the pentazocine-treated cultures were pretreated with 10(-5) M D-arabinofuranosylcytosine (ara-C). In conclusion it is suggested that the overgrowth of fibroblasts, supported by tissue culture study, in tissues other than muscle (i.e. nerve) could explain the neurogenic aspects found in these patients.
报告了两例成瘾患者因喷他佐辛诱发神经肌肉综合征的病例。对远离注射部位的肌肉活检组织进行组织化学和组织学分析，发现II型肌纤维萎缩。为了阐明喷他佐辛的肌毒性机制，进行了一项组织培养研究，并检测了该药物对人胎儿肌肉培养物中肌生成程度的影响。组织培养研究显示：1. 在喷他佐辛处理的人胎儿肌肉培养物中，肌生成完全受阻；2. 当用10(-5) M D-阿拉伯糖胞苷（ara-C）预处理喷他佐辛处理的培养物时，融合过程延迟。总之，组织培养研究支持成纤维细胞在肌肉以外的组织（即神经）中过度生长，这可以解释在这些患者中发现的神经源性方面的问题。
