Perrotta C, Bernardi F, Conconi F, Delazer A, Del Senno L, Marchetti G
Boll Soc Ital Biol Sper. 1980 Jun 15;56(11):1133-6.
Relative alpha and beta chain synthesis in erythroid bursts derived from human bone marrow and peripheral blood are presented. The biosynthetic ratios obtained are compared with those of the reticulocytes. The data obtained cell culture are similar to the "in vivo" ones, showing and alpha/beta ratio of 1 in normal individuals and higher than 1 in beta thalassemic heterozygous. The use of erythroid cell culture as an experimental model for the study of differentiation at molecular level is therefore possible.
本文展示了源自人类骨髓和外周血的红系爆式集落中α链和β链的相对合成情况。将获得的生物合成比率与网织红细胞的比率进行了比较。细胞培养获得的数据与“体内”数据相似，显示正常个体的α/β比率为1，β地中海贫血杂合子的该比率高于1。因此，将红系细胞培养用作分子水平分化研究的实验模型是可行的。
