Polacek I, Mühlbauer H
Biopharm Drug Dispos. 1980 Jan-Mar;1(3):127-32. doi: 10.1002/bdd.2510010307.
Displacement of cephazolin, a highly protein-bound beta-lactam antibiotic, by sulpha-phenazole was studied in vitro and in vivo. In vitro, the sulphonamide was effective in displacing the antibiotic from its binding sites at the concentration 100--1000 mumol 1(-1). In vivo, both the serum and the tissue fluid concentration of free cephazolin increased significantly in rats concomitantly treated with sulphaphenazole.
在体外和体内研究了磺胺苯唑对头孢唑林（一种高度蛋白结合的β-内酰胺抗生素）的置换作用。在体外，磺胺类药物在浓度为100 - 1000 μmol·L⁻¹时能有效将抗生素从其结合位点上置换下来。在体内，同时用磺胺苯唑治疗的大鼠体内游离头孢唑林的血清和组织液浓度均显著升高。
