Owen J A, Nakatsu K
Biopharm Drug Dispos. 1980 Apr-Jun;1(4):179-86. doi: 10.1002/bdd.2510010405.
Theophylline-7-acetic acid (T7AA) was administered intravenously to rabbits so that its distribution and rate of elimination could be ascertained. The analytical techniques used were liquid scintillation counting (14C) and high pressure liquid chromatography. T7AA was eliminated rapidly in the urine; the T 1/2 was 11.6 min. This drug appears to accumulate in the kidney because after 60 min, approximately 15 per cent of the intravenous dose was found in that organ.
将茶碱 - 7 - 乙酸（T7AA）静脉注射给兔子，以便确定其分布和消除速率。所使用的分析技术是液体闪烁计数法（¹⁴C）和高压液相色谱法。T7AA在尿液中迅速消除；半衰期为11.6分钟。这种药物似乎在肾脏中蓄积，因为60分钟后，在该器官中发现了约15%的静脉注射剂量。
