[Changes in hemodynamics and oxygen supply to the body following massive administration of homologous blood by means of an arteriovenous shunt].

In experiments on dogs, exchange normovolemic perfusion of homologous blood by means of arteriovenous bypass resulted in disturbances of blood circulation and development of circulatory hypoxia. This was manifested in a significant slowing of the blood flow, a decrease in cardiac output an abrupt increase in general peripheral resistance that allowed arterial pressure to be maintained at a physiological level. Compensation of hypoxia occurred at the expense of a rise in O2 utilization from inflowing blood.