15种抗肿瘤药物对体外生长的结肠癌的作用：细胞毒性筛选试验（作者译）
[Effect of 15 antineoplastic drugs on colon carcinoma growing in vitro: a screening assay for cytotoxicity (author's transl)].
作者信息
Gouget N, Jeannin J F, Olsson O, Martin F
出版信息
Bull Cancer. 1980;67(2):155-60.
PMID:7448437
Abstract
The cytotoxic effects of 15 drugs used in clinical oncology have been studied on rat colon cancer cells growing in vitro. A 50 per cent cytotoxic activity was obtained with molar concentration from 1.3 10(-8) to more than 4.10(-2), according to the drug. This cheap and quick assay could be useful for screening new drugs or new drug associations to be selected for clinical trials.
摘要
对临床肿瘤学中使用的15种药物在体外培养的大鼠结肠癌细胞上的细胞毒性作用进行了研究。根据药物不同，获得50%细胞毒性活性所需的摩尔浓度为1.3×10⁻⁸至超过4.1×10⁻²。这种廉价且快速的检测方法可用于筛选可供临床试验选择的新药或新药组合。
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