Mollerup C, Cartensen H E, Bruun E, Christiansen L A, Stage G
Br J Surg. 1980 Dec;67(12):890-2. doi: 10.1002/bjs.1800671217.
The high incidence of gastroduodenal ulcers in patients with hyperparathyroidism has been ascribed to gastric hyperacidity induced by hypercalcaemia. In a clinical study comprising 40 patients with solitary parathyroid adenoma, a negative correlation between serum calcium and spontaneous gastric acid secretion was found. At the same time a positive correlation was found between serum calcium and gastrin. It is concluded that gastric hyperacidity is not part of the syndrome provoked by parathyroid adenomas, and that a mechanism inhibitory to gastrin is active in these patients. It is suggested that the inhibitor could be calcitonin.
甲状旁腺功能亢进患者胃十二指肠溃疡的高发病率归因于高钙血症引起的胃酸过多。在一项包含40例孤立性甲状旁腺腺瘤患者的临床研究中，发现血清钙与自发性胃酸分泌之间呈负相关。同时，血清钙与胃泌素之间呈正相关。得出的结论是，胃酸过多不是甲状旁腺腺瘤引发综合征的一部分，并且在这些患者中存在一种抑制胃泌素的机制。有人提出该抑制剂可能是降钙素。
