Blaha G C, Leavitt W W
J Gerontol. 1978 Nov;33(6):810-4. doi: 10.1093/geronj/33.6.810.
Uterine capacity to form cytoplasmic progesterone receptor was compared in ovariectomized golden hamsters at three months and 15-17 months of age. A dose-response test with 17beta-estradiol(E2) showed that the uterine content of progesterone receptor (pmole/uterus) was equal in young and old at all dose levels. However, heavier old uteri had less receptor per gm tissue. Old and young hamsters were mated, ovariectomized on day 7 post coitum and after two weeks, all were given the same dose of E2. Endometrium was separated from myometrium before analysis of progesterone receptor. Myometrium was analyzed for both estrogen and progesterone receptors. Myometrium of both groups had comparable levels of both receptors. The mean concentration of progresterone receptor (pmole/gm tissue) was higher in old endometrium. Some old animals with liver, kidney and adrenal disease had more endometrial reaction after E2 treatment. A few with low endometrial receptor levels had normal livers but at least one sterile uterine horn. There was, however, no general decline with age in intrinsic uterine capacity to form progesterone receptors.
对3个月龄和15 - 17个月龄的去卵巢金黄仓鼠子宫形成细胞质孕酮受体的能力进行了比较。用17β - 雌二醇（E2）进行的剂量反应试验表明，在所有剂量水平下，年轻和年老仓鼠子宫中的孕酮受体含量（皮摩尔/子宫）相等。然而，年老仓鼠较重的子宫每克组织中的受体较少。将年轻和年老的仓鼠进行交配，在交配后第7天进行去卵巢手术，两周后，所有仓鼠都给予相同剂量的E2。在分析孕酮受体之前，将子宫内膜与子宫肌层分离。对子宫肌层进行雌激素和孕酮受体分析。两组的子宫肌层中两种受体的水平相当。年老子宫内膜中孕酮受体的平均浓度（皮摩尔/克组织）较高。一些患有肝脏、肾脏和肾上腺疾病的年老动物在E2治疗后子宫内膜反应更强。少数子宫内膜受体水平较低的动物肝脏正常，但至少有一个子宫角不育。然而，子宫形成孕酮受体的内在能力并没有随着年龄的增长而普遍下降。
