Conrad K A
Circulation. 1981 Feb;63(2):371-7. doi: 10.1161/01.cir.63.2.371.
Atropine was given intravenously to 10 normal volunteers in increments of 0.01 mg/kg to a total dose of 0.04 mg/kg. This produced an increase in heart rate from 65 +/- 11 to 112 +/- 14 beats/min, a decrease in diastolic time from 534 +/- 131 to 180 +/- 65 msec, and a decrease in percent diastole from 55.6 +/- 5.3% to 32.4 +/- 7.2% (p < 0.001). Administration of isoproterenol in doses that increased heart rate from 69 +/- 9 to 99 +/- 12 beats/min produced a decrease in diastolic time from 485 +/- 98 to 312 +/- 47 msec and only a slight decrease in percent diastole, from 54.2 +/- 4.3% to 50.6 +/- 3.9%. Atropine, in doses commonly used clinically, may significantly reduce diastolic time and the percent diastole. Because diastolic time is an important determinant of coronary perfusion, administration of atropine to patients with coronary artery disease may increase myocardial ischemia.
对10名正常志愿者静脉注射阿托品，剂量以0.01mg/kg递增，直至总剂量达到0.04mg/kg。这使得心率从65±11次/分钟增加到112±14次/分钟，舒张期时间从534±131毫秒减少到180±65毫秒，舒张期百分比从55.6±5.3%降至32.4±7.2%（p<0.001）。给予异丙肾上腺素，使心率从69±9次/分钟增加到99±12次/分钟，这导致舒张期时间从485±98毫秒减少到312±47毫秒，而舒张期百分比仅略有下降，从54.2±4.3%降至50.6±3.9%。临床常用剂量的阿托品可能会显著缩短舒张期时间和舒张期百分比。由于舒张期时间是冠状动脉灌注的一个重要决定因素，给冠状动脉疾病患者使用阿托品可能会增加心肌缺血。
