Crane J, Burgess C, Beasley R
Department of Medicine, Wellington School of Medicine, New Zealand.
Thorax. 1989 Feb;44(2):136-40. doi: 10.1136/thx.44.2.136.
The cardiovascular and hypokalaemic effects of equal doses of inhaled fenoterol, isoprenaline and salbutamol were compared in eight healthy male volunteers, in a double blind, placebo controlled study. Increasing doses of 400, 600, and 800 micrograms were given from a metered dose inhaler at 15 minute intervals, followed by measurements of heart rate, blood pressure, total electromechanical systole (as a measure of inotropic response), QTc interval, and plasma potassium concentration. After repeated inhalation, fenoterol resulted in significantly greater chronotropic, electrocardiographic, and hypokalaemic effects than either isoprenaline or salbutamol. The maximum inotropic effect of fenoterol was similar to that of isoprenaline.
在一项双盲、安慰剂对照研究中，对8名健康男性志愿者比较了等量吸入的非诺特罗、异丙肾上腺素和沙丁胺醇对心血管及低钾血症的影响。通过定量吸入器每隔15分钟给予递增剂量的400、600和800微克药物，随后测量心率、血压、总电机械收缩期（作为变力反应的指标）、QTc间期和血浆钾浓度。重复吸入后，非诺特罗导致的变时性、心电图及低钾血症效应显著大于异丙肾上腺素或沙丁胺醇。非诺特罗的最大变力效应与异丙肾上腺素相似。
