Leeming R J, Blair J A
Clin Chim Acta. 1980 Nov 20;108(1):103-11. doi: 10.1016/0009-8981(80)90298-3.
Mean serum biopterin derivative levels in adult males and females were 1.75 microgram/l and 1.53 microgram/l respectively, increased with age and followed a cyclic pattern during menstruation. Foetal brain and liver levels at 16 weeks approximated adult concentrations. Wide distribution in adult tissues and variation in concentration independent of serum levels demonstrated local synthesis. Serum levels were significantly decreased in senile dementia, lead poisoning, coeliac disease and malignant carcinoid disease. Abnormal metabolism of phenylalanine in senile dementia suggest lowered levels of tetrahydrobiopterin in tissue. Methotrexate increased serum biopterin levels by inhibition of dihydropteridine reductase; a saturation effect was noted.
成年男性和女性血清生物蝶呤衍生物的平均水平分别为1.75微克/升和1.53微克/升，随年龄增长而升高，且在月经期间呈周期性变化。16周时胎儿脑和肝脏中的水平接近成人浓度。生物蝶呤在成体组织中分布广泛，其浓度变化与血清水平无关，表明存在局部合成。在老年痴呆症、铅中毒、乳糜泻和恶性类癌病中，血清水平显著降低。老年痴呆症中苯丙氨酸的代谢异常表明组织中四氢生物蝶呤水平降低。甲氨蝶呤通过抑制二氢蝶啶还原酶增加血清生物蝶呤水平；存在饱和效应。
