盐负荷引起的自发性高血压大鼠交感神经活动增强。

Enhanced sympathetic activity caused by salt loading in spontaneously hypertensive rats.

Dietz R, Schömig A, Rascher W, Strasser R, Kübler W

Clin Sci (Lond). 1980 Dec;59 Suppl 6:171s-173s. doi: 10.1042/cs059171s.

Abstract

Salt loading accelerates and increases the rise in blood pressure (spSH) in stroke-prone spontaneously hypertensive rats, but not in Wistar-Kyoto (WK) rats. 2. In both strains a slight increase in plasma volume was obtained during salt loading. 3. Salt loading caused a distinct increase in plasma noradrenaline concentration in spSH rats, but a slight decrease in WK rats. Plasma adrenaline and dopamine concentrations remained unaffected. 4. Exposure to cold resulted in a more marked stimulation of sympathoadrenal and sympathoneuronal activity in salt-loaded spSH rats than in spSH rats on a normal sodium diet. 5. It is concluded that salt loading results in a further increase of the already elevated sympathetic activity in spSH rats.

摘要

盐负荷会加速并加剧易患中风的自发性高血压大鼠的血压升高（spSH），但对Wistar-Kyoto（WK）大鼠无此影响。2. 在两种品系的大鼠中，盐负荷期间血浆容量均有轻微增加。3. 盐负荷使spSH大鼠血浆去甲肾上腺素浓度显著升高，而使WK大鼠血浆去甲肾上腺素浓度略有降低。血浆肾上腺素和多巴胺浓度未受影响。4. 与正常钠饮食的spSH大鼠相比，暴露于寒冷环境会使盐负荷的spSH大鼠的交感肾上腺和交感神经活动受到更显著的刺激。5. 得出的结论是，盐负荷导致spSH大鼠本已升高的交感神经活动进一步增强。