自发性高血压大鼠和Wistar-Kyoto大鼠下丘脑前部高血压中的全身和局部血流动力学

Systemic and regional haemodynamics in anterior hypothalamic hypertension in spontaneously hypertensive and Wistar-Kyoto rats.

Suarez D H, Pegram B L, Frohlich E D

Clin Sci (Lond). 1980 Dec;59 Suppl 6:251s-253s. doi: 10.1042/cs059251s.

Abstract

Systemic and regional haemodynamics were determined in conscious Wistar-Kyoto and spontaneously hypertensive rats with the radioactive microsphere technique after sham lesion or bilateral electrolytic lesion of the nuclei of the anterior hypothalamus. 2. Anterior hypothalamic lesions produced an increase in blood pressure, heart rate and cardiac output. 3. In the rats with lesions there were changes in regional haemodynamics: heart and skeletal muscle flow increased; renal, skin ans splanchnic flow decreased. 4. The haemodynamic consequences of ablation of the anterior hypothalamus were similar in both normotensive Wistar-Kyoto and spontaneously hypertensive rats. The haemodynamic pattern resembles that seen during fighting and exercise.

摘要

运用放射性微球技术，在假损伤或双侧电解损毁前下丘脑核团后，对清醒的Wistar-Kyoto大鼠和自发性高血压大鼠的全身及局部血流动力学进行测定。2. 前下丘脑损伤导致血压、心率和心输出量增加。3. 有损伤的大鼠局部血流动力学发生变化：心脏和骨骼肌血流量增加；肾脏、皮肤和内脏血流量减少。4. 正常血压的Wistar-Kyoto大鼠和自发性高血压大鼠前下丘脑切除后的血流动力学后果相似。血流动力学模式类似于战斗和运动时所见的模式。