自发性高血压大鼠和Wistar-Kyoto正常血压大鼠的中心血容量

Central blood volume in spontaneously hypertensive rats and Wistar-Kyoto normotensive rats.

Lundin S, Folkow B, Friberg P, Rippe B

Clin Sci (Lond). 1980 Dec;59 Suppl 6:389s-391s. doi: 10.1042/cs059389s.

Abstract

Central blood volume and total blood volume were determined in spontaneously hypertensive rats and Wistar-Kyoto rats at two ages (6 and 12 weeks), representing 'borderline' hypertension and early 'established' hypertension. 2. A technique was used where plasma and erythrocyte indicators were injected into conscious rats. Blood volume in the cardiopulmonary compartment, present in the 'resting' awake steady state, could then be estimated by sudden freezing of the entire rat. 3. Twelve week-old spontaneously hypertensive rats showed a decreased total blood volume, and the fraction of blood contained in the cardiopulmonary area was significantly increased compared with that of normotensive Wistar-Kyoto rats. 4. In 6 week-old spontaneously hypertensive rats, total blood volume was only marginally decreased but here also a tendency towards centralization of the blood was seen. 5. Thus, along with the development of spontaneously hypertensive rat hypertension, a decreasing blood volume tends to become increasingly centralized to the cardiopulmonary area. Both neuro-hormonal influences and structural wall changes in the low-pressure capacitance side may contribute to this.

摘要

在两个年龄段（6周和12周）的自发性高血压大鼠和Wistar-Kyoto大鼠中测定了中心血容量和总血容量，这两个年龄段分别代表“临界”高血压和早期“确立”高血压。2. 使用了一种技术，将血浆和红细胞指标注入清醒的大鼠体内。然后，通过突然冷冻整个大鼠，可以估算处于“静息”清醒稳态的心肺腔室中的血容量。3. 12周龄的自发性高血压大鼠总血容量减少，与正常血压的Wistar-Kyoto大鼠相比，心肺区域所含血液的比例显著增加。4. 在6周龄的自发性高血压大鼠中，总血容量仅略有减少，但此处也可见血液向中心集中的趋势。5. 因此，随着自发性高血压大鼠高血压的发展，血容量减少倾向于越来越多地集中到心肺区域。神经激素影响和低压容量侧的结构壁变化可能都对此有作用。