Budd R D
Clin Toxicol. 1980 Oct;17(3):375-82. doi: 10.3109/15563658008989986.
The gas chromatographic properties of 1,3-dialkyl barbiturates have been studied. The retention times for 56 different 1,3-dialkyl derivatives of both aprobarbital and phenobarbital, and for 65 different 1,3-dialkyl derivatives of secobarbital were determined by gas-liquid chromatography (GLC) using a 3% SE-30 column. Retention times were found to increase with the number of carbons added. A plot of the log of the retention time versus the number of carbons in the alkyl group added for 3-alkyl derivatives of 1-alkylbarbiturates was made for each of the three barbiturates studied. A linear relationship was found to exist for derivatives having butyl or greater groups attached to the second nitrogen of the 1-alkylbarbiturates. The slopes of the graphs for the 3-alkyl derivatives of 10 different 1-alkylbarbiturates for each barbiturate studied were all found to be identical with a similar plot for straight chain hydrocarbons. This linear relationship allowed calculation of the retention times of large N,N-dialkyl barbiturates, such as N,N-eicosanylsecobarbital, which are not readily synthesized or chromatographed.
对1,3 - 二烷基巴比妥酸盐的气相色谱性质进行了研究。使用3% SE - 30柱通过气液色谱法（GLC）测定了阿普巴比妥和苯巴比妥的56种不同1,3 - 二烷基衍生物以及司可巴比妥的65种不同1,3 - 二烷基衍生物的保留时间。发现保留时间随添加的碳原子数增加而增加。针对所研究的三种巴比妥酸盐中的每一种，绘制了1 - 烷基巴比妥酸盐的3 - 烷基衍生物的保留时间的对数与添加的烷基中碳原子数的关系图。发现对于在1 - 烷基巴比妥酸盐的第二个氮原子上连接有丁基或更大基团的衍生物存在线性关系。对于所研究的每种巴比妥酸盐，10种不同1 - 烷基巴比妥酸盐的3 - 烷基衍生物的图形斜率与直链烃的类似图形均相同。这种线性关系使得能够计算不易合成或进行色谱分析的大的N,N - 二烷基巴比妥酸盐（如N,N - 二十烷基司可巴比妥）的保留时间。
