Vaziri N D, Upham T, Barton C H
Clin Toxicol. 1980 Oct;17(3):451-6. doi: 10.3109/15563658008989995.
We studied the clearance of arsenic by hemodialysis in two patients with acute sodium arsenite intoxication and acute renal failure. Blood arsenic concentration fell considerably with dialysis. The dialysance of arsenic ranged between 76 and 87 mL/min. Total arsenic removal by 4 h of hemodialysis exceeded its 24 hr urinary excretion while renal function was impaired. With improvement of renal function, urinary arsenic excretion increased remarkably and dialysis treatments were discontinued. Based on these result, hemodialysis is a useful adjunct in the treatment of acute arsenic poisoning with concomitant renal failure.
我们研究了血液透析对两名急性亚砷酸钠中毒并伴有急性肾衰竭患者体内砷的清除情况。透析过程中血液砷浓度显著下降。砷的透析率在76至87毫升/分钟之间。在肾功能受损时，4小时血液透析清除的总砷量超过了其24小时尿排泄量。随着肾功能的改善，尿砷排泄显著增加，透析治疗停止。基于这些结果，血液透析是治疗伴有肾衰竭的急性砷中毒的一种有效辅助手段。
