Neuhaus K L, Wurm K, Köstering H, Tebbe U, Nebel H, Kreuzer H
Dtsch Med Wochenschr. 1980 Oct 3;105(40):1392-5. doi: 10.1055/s-2008-1070878.
Streptokinase (290 000 U/2 h) was directly infused under angiographic control into the predominantly affected right pulmonary artery in a 71-year-old patient with acute pulmonary embolism and persistent shock. This led to immediate complete remission of shock symptoms and lasting stabilisation of the patient. If, as this case demonstrates, embolectomy is not possible and high-dose intravenous streptokinase is contraindicated, localised use of streptokinase in low dosage offers a possibility for treatment of life-threatening pulmonary embolism.
在血管造影控制下，将链激酶（290000单位/2小时）直接注入一名71岁急性肺栓塞且持续休克患者主要受累的右肺动脉。这立即导致休克症状完全缓解，患者病情持续稳定。如果像该病例所示，无法进行栓子切除术且大剂量静脉注射链激酶存在禁忌，那么低剂量局部使用链激酶为治疗危及生命的肺栓塞提供了一种可能性。
