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γ-氨基丁酸（GABA）和地西泮对海马突触体3H-5-羟色胺释放的影响。

Effects of GABA and diazepam on 3H-serotonin release from hippocampal synaptosomes.

作者信息

Balfour D J

出版信息

Eur J Pharmacol. 1980 Nov 7;68(1):11-6. doi: 10.1016/0014-2999(80)90054-0.

DOI:10.1016/0014-2999(80)90054-0
PMID:7449830
Abstract

The effects of GABA and diazepam on the spontaneous and potassium-evoked release of 3H-5-HT from rat hippocampal synaptosomes, preloaded by incubation with 3H-5-HT, have been investigated. Both GABA and diazepam independently increased the spontaneous release of 5-HT whereas they blocked the calcium-dependent, potassium-evoked release. However diazepam antagonised the GABA-mediated increase in spontaneous release but enhanced the inhibitory effects of GABA on potassium-stimulated release. The results suggest that 5-HT release in the hippocampus is under the presynaptic control of GABA and that diazepam may selectively enhance the inhibitory effect of GABA on the evoked release of 5-HT.

摘要

通过与3H-5-羟色胺（3H-5-HT）共同孵育预加载后，研究了γ-氨基丁酸（GABA）和地西泮对大鼠海马突触体中3H-5-HT的自发释放和钾诱发释放的影响。GABA和地西泮均可独立增加5-羟色胺（5-HT）的自发释放，同时它们会阻断钙依赖性的钾诱发释放。然而，地西泮可拮抗GABA介导的自发释放增加，但增强了GABA对钾刺激释放的抑制作用。结果表明，海马体中5-HT的释放受GABA的突触前控制，并且地西泮可能选择性增强GABA对5-HT诱发释放的抑制作用。

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