对大鼠进行慢性地西泮治疗会导致中枢[3H]-5-羟色胺和[14C]-γ-氨基丁酸释放产生长期变化。
Chronic diazepam treatment in rats causes long-lasting changes in central [3H]-5-hydroxytryptamine and [14C]-gamma-aminobutyric acid release.
作者信息
Hitchcott P K, File S E, Ekwuru M, Neal M J
机构信息
Psychopharmacology Research Unit, UMDS, Guy's Hospital, London.
出版信息
Br J Pharmacol. 1990 Jan;99(1):11-2. doi: 10.1111/j.1476-5381.1990.tb14644.x.
Abstract
The effects of chronic diazepam administration to rats on the central release of [3H]-5-hydroxytryptamine ([3H]-5-HT) and [14C]-gamma-aminobutyric acid ([14C]-GABA, ex vivo) were examined. Chronic (5 and 21 days) administration of diazepam (4 mg kg-1 i.p. daily for 21 days) reduced the K-evoked (20 mM KCl) release of [3H]-5-HT from frontal cortex by approximately 50%. Remarkably, this decrease was still present 1 week after diazepam withdrawal. Chronic diazepam treatment did not significantly affect hippocampal [3H]-5-HT release but after 21 days the K-evoked release of [14C]-GABA was more than doubled and remained elevated 30 h after withdrawal; it returned to control levels after 1 week, and decreased below control levels after 2 weeks. This study indicates that chronic diazepam treatment produces striking changes in transmitter release in rats that persist long after treatment has ceased.
摘要
研究了长期给大鼠注射地西泮对[3H]-5-羟色胺（[3H]-5-HT）和[14C]-γ-氨基丁酸（[14C]-GABA，离体）中枢释放的影响。长期（5天和21天）注射地西泮（每天腹腔注射4mg/kg，共21天）使额叶皮质中钾离子诱发（20mM氯化钾）的[3H]-5-HT释放减少了约50%。值得注意的是，在地西泮停药1周后，这种减少仍然存在。长期地西泮治疗对海马体中[3H]-5-HT的释放没有显著影响，但在21天后，钾离子诱发的[14C]-GABA释放增加了一倍多，停药后30小时仍保持升高；1周后恢复到对照水平，2周后降至对照水平以下。这项研究表明，长期地西泮治疗会使大鼠的神经递质释放产生显著变化，且在治疗停止后仍会持续很长时间。
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本文引用的文献
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