培高利特对大鼠纹状体中腺苷酸环化酶的刺激作用：GTP的影响
Stimulation of adenylate cyclase in rat striatum by pergolide: influence of GTP.
作者信息
Rosenfeld M R, Makman M H, Goldstein M
出版信息
Eur J Pharmacol. 1980 Nov 7;68(1):65-8. doi: 10.1016/0014-2999(80)90062-x.
PMID:7449835
Abstract
Pergolide stimulates adenylate cyclase activity in homogenates of rat striatum. In contrast, bromocriptine and lisuride are inactive. GTP enhances the stimulation produced by pergolide and has no effect on the other ergots tested. The stimulation produced by pergolide is inhibited by haloperidol but not by molindone. It is concluded that pergolide acts as an agonist at dopaminergic receptors coupled to adenylate cyclase in rat striatum.
摘要
培高利特可刺激大鼠纹状体匀浆中的腺苷酸环化酶活性。相比之下，溴隐亭和利舒脲则无此活性。鸟苷三磷酸（GTP）可增强培高利特产生的刺激作用，而对所测试的其他麦角生物碱则无影响。培高利特产生的刺激作用可被氟哌啶醇抑制，但不受吗茚酮抑制。由此得出结论，培高利特在大鼠纹状体中作为与腺苷酸环化酶偶联的多巴胺能受体的激动剂发挥作用。
Zotero 插件