Srdić Z, Frei H
Differentiation. 1980;17(3):187-92. doi: 10.1111/j.1432-0436.1980.tb01095.x.
The pleiotropic mutant lethal(3)giant larvae [l(3)gl] of Drosophila hydei exhibits among other anatomical defects, hypertrophy of the larval brain and imaginal discs. both hypertrophic tissues when transplanted into wild-type female flies behave as fast growing and lethal neoplasms. Implanted into mature wild-type larvae they fail to metamorphose. When l(3)gl neoplastic brain tissue or imaginal discs were mixed with normal imaginal discs, cultured in vivo in the abdomen of adult females and transplanted into mature wild-type larvae, the following results were obtained. The invasive l(3)gl brain neoplasm, while fatal for adult hosts, had no effect on the metamorphosis of normal imaginal disc tissue. On the other hand, the noninvasive l(3)gl imaginal disc neoplasms when mixed with normal imaginal disc tissue inhibited its development and metamorphosis in the wild-type host. This inhibitory effect was not observed when the tissues were injected as separate implants into the same host.
海德果蝇的多效性突变致死（3）巨幼虫[l（3）gl]除了其他解剖学缺陷外，还表现出幼虫大脑和成虫盘肥大。当将这两种肥大组织移植到野生型雌蝇中时，它们表现为快速生长且致死的肿瘤。植入成熟的野生型幼虫后，它们无法变态。当将l（3）gl肿瘤性脑组织或成虫盘与正常成虫盘混合，在成年雌性腹部进行体内培养并移植到成熟的野生型幼虫中时，得到了以下结果。侵袭性的l（3）gl脑肿瘤对成年宿主是致命的，但对正常成虫盘组织的变态没有影响。另一方面，非侵袭性的l（3）gl成虫盘肿瘤与正常成虫盘组织混合时，会抑制其在野生型宿主中的发育和变态。当将这些组织作为单独的植入物注射到同一宿主中时，未观察到这种抑制作用。
