Kobayashi K, Yamada H, Mitani E
Gastroenterol Jpn. 1980;15(6):570-6. doi: 10.1007/BF02773760.
The movement of the terminal part of the bile duct in rabbits and humans were recorded by a pressure sensor, and the effect of CCK-PZ to the movement were examined. The movement of the terminal part of the rabbit bile duct was accelerated immediately after giving a large dose of CCK-PZ intravenously but this was suppressed by slow intravenous administration of a small dose of CCK-PZ. The effect of CCK-PZ was inhibited by secretin but it was not affected by pretreatment with vagotomy. In patients, the effect of CCK-PZ on the movement of the terminal part of the bile duct was measured with a pressure sensor using a duodenofiberscope. Following 1 to 2 u/kg of CCK-PZ intravenously, this movement was immediately reduced and the regular wave pattern usually disappeared. This continued for several minutes but later this was accelerated gradually and then excretion of bile was seen from the papillary orifice. These results indicate that the intravenous administration of CCK-PZ increased activity of the papillary movement to promote the smooth excretion of bile in rabbits and humans.
通过压力传感器记录兔和人胆管末端的运动，并检测胆囊收缩素-促胰酶素（CCK-PZ）对该运动的影响。静脉注射大剂量CCK-PZ后，兔胆管末端的运动立即加速，但缓慢静脉注射小剂量CCK-PZ可抑制此运动。促胰液素可抑制CCK-PZ的作用，但迷走神经切断术预处理对其无影响。在患者中，使用十二指肠纤维镜通过压力传感器测量CCK-PZ对胆管末端运动的影响。静脉注射1至2单位/千克CCK-PZ后，该运动立即减弱，规则的波形通常消失。这种情况持续数分钟，但随后逐渐加速，随后可见胆汁从乳头口排出。这些结果表明，静脉注射CCK-PZ可增加乳头运动活性，促进兔和人胆汁的顺利排泄。
