Hosoda S, Ikedo H, Saito T
Gastroenterology. 1981 Jan;80(1):16-21.
Praomys (Mastomys) natalensis, an African rodent ranging in size between a mouse and a rat, is more susceptible to the induction of duodenal ulcers by constant infusion of exogenous histamine through an osmotic minipump implanted subcutaneously than other rodent species tested such as mouse, rat, or guinea-pig. By increasing the doses of infused histamine, there were increases in the incidence, intensity, and perforation rate of duodenal ulcers in Mastomys. The induction of duodenal ulcers in Mastomys by tetra- and pentagastrins was unsuccessful, probably because of the limited releasing capacity of the present minipump for use of these two peptides which were sparingly soluble in water. More soluble human synthetic gastrin I was approximately three to four times as potent as histamine for inducing duodenal ulcers in Mastomys. The susceptibility of Mastomys to the induction of duodenal ulcer by cysteamine appears to be comparable to that of rat. The complete suppression of histamine-induced duodenal ulcers of Mastomys was possible by repeated subcutaneous injections of cimetidine.
南非小鼠（多乳鼠属）是一种非洲啮齿动物，大小介于小鼠和大鼠之间。与其他受试啮齿动物物种（如小鼠、大鼠或豚鼠）相比，通过皮下植入的渗透微型泵持续输注外源性组胺，它更容易诱发十二指肠溃疡。通过增加输注组胺的剂量，南非小鼠十二指肠溃疡的发生率、严重程度和穿孔率均有所增加。用四肽胃泌素和五肽胃泌素诱导南非小鼠十二指肠溃疡未成功，可能是因为现有的微型泵释放这两种在水中溶解度低的肽的能力有限。在诱导南非小鼠十二指肠溃疡方面，更易溶解的人合成胃泌素I的效力约为组胺的三到四倍。南非小鼠对半胱胺诱导十二指肠溃疡的易感性似乎与大鼠相当。通过反复皮下注射西咪替丁，可以完全抑制组胺诱导的南非小鼠十二指肠溃疡。
