一名XYY胎儿的大脑皮质脑回异常。

Abnormal cerebral cortical convolutions in an XYY fetus.

作者信息

Austin G E, Sparkes R S

出版信息

Hum Genet. 1980;56(2):173-5. doi: 10.1007/BF00295690.

Abstract

Because of maternal disease a pregnancy was electively terminated at 21 weeks of fetal gestation. At autopsy the fetus showed an abnormal pattern of cerebral cortical convolutions involving the frontal lobes. Karyotpic analysis revealed an XYY sec chromosome constitution. This observation, if confirmed in other XYY cases, raises the possibility that a developmental abnormality of the cerebral cortex may be involved in the higher-than-normal risk for behavioral disability exhibited by men with this genotype.

摘要

由于母亲患病，在胎儿妊娠21周时选择性终止了妊娠。尸检显示胎儿额叶的大脑皮质脑回模式异常。核型分析显示性染色体组成为XYY。如果在其他XYY病例中得到证实，这一观察结果增加了一种可能性，即这种基因型男性所表现出的高于正常水平的行为障碍风险可能与大脑皮质的发育异常有关。