Masterson E, Chader G J
Invest Ophthalmol Vis Sci. 1981 Jan;20(1):1-7.
The phagocytosis of bovine rod outer segments as measured by the uptake of 3H-labeled outer segments was studied in a culture system. Phagocytosis was markedly inhibited by the lack of glucose and by two inhibitors of the tricarboxylic acid cycle-cytochrome system, dinitrophenol and malonate. Lactate production was increased in phagocytizing cells, but the hexose monophosphate shunt was not stimulated. The data support the conclusion that the tricarboxylic acid cycle and its associated cytochrome system play an important role as an energy source for phagocytosis in these cells. Compromise of this energy source rapidly leads to a suppression of the phagocytic process.
在一个培养系统中研究了通过摄取³H标记的牛视杆细胞外节来测定的吞噬作用。葡萄糖缺乏以及三羧酸循环 - 细胞色素系统的两种抑制剂（二硝基苯酚和丙二酸）显著抑制了吞噬作用。在进行吞噬作用的细胞中乳酸生成增加，但磷酸己糖旁路未被激活。这些数据支持这样的结论：三羧酸循环及其相关的细胞色素系统作为这些细胞吞噬作用的能量来源发挥着重要作用。这种能量来源的受损会迅速导致吞噬过程的抑制。
