Ashkenazi A, Levin S, Miskin A
Isr J Med Sci. 1980 Dec;16(12):843-6.
Serum immunoglobulins were evaluated in 110 children with celiac disease ranging in age from three months to 15 years. IgG, IgM and IgA were evaluated in all the patients when they were on either a normal or a gluten-free diet and the findings were analyzed by age and type of diet. IgG and IgM levels were generally higher than normal. The type of diet did not affect the results. IgA levels were higher in untreated (normal diet) than in treated (gluten-free diet) celiac patients or normal subjects. The IgA levels returned to normal when the patients were on a gluten-free diet. The variations in immunoglobulin levels among the different age groups of celiac patients reflect the normal variations in serum immunoglobulins with age. It is suggested that the higher IgA levels in untreated celiac disease patients are evidence of chronic stimulation of the B cell immune system and that this could be a factor in the high incidence of lymphoreticular abnormalities and malignant tumors in adults with celiac disease.
对110名年龄在3个月至15岁之间的乳糜泻患儿进行了血清免疫球蛋白评估。在所有患者采用正常饮食或无麸质饮食时，对其IgG、IgM和IgA进行了评估，并按年龄和饮食类型对结果进行了分析。IgG和IgM水平通常高于正常水平。饮食类型不影响结果。未治疗（正常饮食）的乳糜泻患者的IgA水平高于接受治疗（无麸质饮食）的乳糜泻患者或正常受试者。当患者采用无麸质饮食时，IgA水平恢复正常。乳糜泻患者不同年龄组免疫球蛋白水平的变化反映了血清免疫球蛋白随年龄的正常变化。有人认为，未治疗的乳糜泻患者中较高的IgA水平是B细胞免疫系统慢性刺激的证据，这可能是成年乳糜泻患者淋巴网状异常和恶性肿瘤高发的一个因素。
