大鼠在卟啉症实验研究中的应用。
The use of the rat in the experimental investigation of the porphyrias.
作者信息
Eales L, Blekkenhorst G H
出版信息
J S Afr Vet Assoc. 1978 Sep;49(3):249-51.
PMID:745206
Abstract
The patterns of urinary porphyria excretion and hepatic porphyrin accumulation in hexachlorobenzene-treated rats is similar to that observed in overt porphyria cutanea tarda and may be attributed to a decrease in activity of hepatic uroporphyrinogen (UROGEN) decarboxylase. The 3.5 diethoxycarbonyl-1,4-dihydrocollidine (DDC)-treated rat has been evaluated as a model to test the porphyrinogenicity of drugs.
摘要
六氯苯处理的大鼠尿卟啉排泄模式和肝卟啉蓄积情况与迟发性皮肤卟啉病明显期所观察到的相似，这可能归因于肝尿卟啉原（UROGEN）脱羧酶活性降低。3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁（DDC）处理的大鼠已被评估为一种用于测试药物卟啉ogenicity的模型。
Zotero 插件