Effect of alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide (Sch 16423) on serum testosterone and LH in rats.

Administration of Sch 16423 to intact male rats (5 mg/day s.c. for 7 days) resulted in a rapid and dramatic rise in the serum concentrations of LH and testosterone. This suggests that this metabolite of flutamide is the active antiandrogenic agent.