新生大鼠氢化可的松治疗对发育中大鼠脑单胺的影响。
Effect of neonatal hydrocortisone treatment on brain monoamines in developing rats.
作者信息
Kurosawa A, Kageyama H, John T M, Hirota R, Itoh S
出版信息
Jpn J Pharmacol. 1980 Apr;30(2):213-20. doi: 10.1254/jjp.30.213.
In our previous study, neonatal treatment with hydrocortisone was shown to produce a marked retardation of pituitary-adrenocortical development in infant rats. The present investigation was an attempt to determine whether or not the retarded activity is caused by functional changes in brain monoamine systems. In rats treated with hydrocortisone (0.5 mg/rat, s.c.) on the 2nd day of life, the development of whole brain was suppressed significantly. However, norepinephrine, dopamine and serotonin contents in the brain were higher in these rats than controls. These changes of monoamine contents were apparent in the hypothalamus, diencephalon and pons-medulla oblongata. Our data suggest that monoaminergic nervous systems are potentiated with hydrocortisone in these brain regions, although the results do not necessarily explain the retarded hypothalamo-pituitary function.
在我们之前的研究中，已表明氢化可的松对新生大鼠的治疗会导致幼鼠垂体 - 肾上腺皮质发育显著迟缓。本研究旨在确定这种发育迟缓是否由脑单胺系统的功能变化引起。在出生后第2天接受氢化可的松（0.5毫克/只，皮下注射）治疗的大鼠中，全脑发育受到显著抑制。然而，这些大鼠脑中去甲肾上腺素、多巴胺和5-羟色胺的含量高于对照组。单胺含量的这些变化在下丘脑、间脑和脑桥 - 延髓中很明显。我们的数据表明，在这些脑区中，单胺能神经系统因氢化可的松而增强，尽管这些结果不一定能解释下丘脑 - 垂体功能的迟缓。
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