Schoen F J, Hausner R J, Howell J F, Beazley H L, Titus J L
J Thorac Cardiovasc Surg. 1981 Jan;81(1):100-5.
A 53-year-old man with a pancreatic carcinoid tumor and liver metastases had the carcinoid syndrome with involvement of the tricuspid valve by carcinoid plaque. The mitral valve was involved by unrelated myxomatous degeneration (floppy valve). Each valve was replaced by a Hancock glutaraldehyde-prepared porcine heterograft prosthesis. When the patient died of complications of the tumor 8 months postoperatively, both valves had clinically normal function. Nevertheless, the carcinoid plaque, which was present in all four cardiac chambers and almost completely covered the endocardial surfaces of both atria, extended onto both prostheses. This eventually might have interfered with prosthetic valve function.
一名53岁男性患有胰腺类癌瘤并伴有肝转移，出现类癌综合征，三尖瓣被类癌斑块累及。二尖瓣则患有无关的黏液瘤样变性（瓣膜松弛）。每个瓣膜均被替换为经戊二醛处理的汉考克猪异种移植人工瓣膜。患者术后8个月死于肿瘤并发症时，两个瓣膜在临床上功能正常。然而，存在于所有四个心腔且几乎完全覆盖两个心房内膜表面的类癌斑块延伸至两个人工瓣膜上。这最终可能会干扰人工瓣膜的功能。
