Miron C, Stoica G, Angelescu M, Michiu V, Rădulescu E, Tănăsescu C
Med Interne. 1980 Oct-Dec;18(4):391-9.
Thirty-five patients showing quatitative deviations from normal of the M and G immunoglobulin (Ig) fractions were selected for study from a larger group of patients with viral hepatitis. In 15 of the 35 cases, most of which showed high IgM and/or IgG serum levels, moderate doses of prednisone were administered for 60 days. Determinations of Ig levels were performed before and after corticotherapy, two and four months respectively after the onset of the acute viral hepatitis. The rest of 20 patients were used as controls. In the cases in which the clinical and biological parameters indicated an improvement after treatment, the initial high IgM titers showed a tendency to decrease while in those with severe evolution, IgM levels increased. A similar behaviour of IgM titers, though less marked, was also noticed in the control group, of untreated patients. These variations are assumed to predict the further favourable of severe course of the disease; Ig variations and particularly the IgM ones, might be useful criteria for the selection of cases with high risk of developing chronic hepatitis, so that corticotherapy could be applied in the early stages, to prevent the progress to more severe forms of the disease.
从一大群病毒性肝炎患者中挑选出35名M和G免疫球蛋白（Ig）组分定量偏离正常的患者进行研究。在这35例患者中，有15例大部分表现为血清IgM和/或IgG水平升高，给予中等剂量的泼尼松治疗60天。在皮质激素治疗前以及急性病毒性肝炎发病后两个月和四个月分别进行Ig水平测定。其余20名患者作为对照。在治疗后临床和生物学参数显示改善的病例中，最初较高的IgM滴度有下降趋势，而在病情严重进展的病例中，IgM水平升高。在未治疗患者的对照组中也观察到IgM滴度有类似变化，尽管不太明显。这些变化被认为可预测疾病进一步发展的有利或严重程度；Ig变化，尤其是IgM变化，可能是选择有发展为慢性肝炎高风险病例的有用标准，以便在疾病早期应用皮质激素治疗，防止病情进展为更严重的形式。
