苯妥英钠诱导的致畸作用：小鼠模型

Science. 1981 Jan 30;211(4481):483-4. doi: 10.1126/science.7455686.

Malformations associated with the fetal hydantoin syndrome have been reproduced in a mouse model. The occurrence of these defects was correlated with maternal serum concentrations, but not with maternal or fetal genotype or the presence of a seizure disorder.

与胎儿苯妥英综合征相关的畸形已在小鼠模型中重现。这些缺陷的发生与母体血清浓度相关，但与母体或胎儿基因型或癫痫症的存在无关。