Erikssen J, Thaulow E, Stormorken H, Brendemoen O, Hellem A
Thromb Haemost. 1980 Jun 18;43(2):137-40.
The view based on epidemiological and laboratory data that blood group A subjects (=A) have clinically significant higher thrombotic potential than blood group 0 subjects (=O), is supported by the present finding of a significantly higher platelet retention in A than 0. The completely normal AB0 distribution found among 71 cases of proven latent CHD, and the disproportionate excess of 0 vs. A in a consecutive series of 191 coronary artery bypass candidates apparently conflict with epidemiological data indicating a higher risk of achieving CHD in A than 0. The conflict may be solved by suggesting a) that the "thrombotic proneness" in A compared with 0 causes a poorer prognosis in CHD among the former, leaving a disproportionate excess of 0 among longterm CHD survivors, and b) that AB0-related factors have had an insignificant, independent impact on the evolution of preclinical coronary artery disease in our 71 men with latent CHD.
基于流行病学和实验室数据的观点认为，A型血个体（=A）在临床上具有比O型血个体（=O）显著更高的血栓形成潜能，目前发现A组血小板滞留率明显高于O组，这支持了上述观点。在71例经证实的隐匿性冠心病病例中发现的ABO血型分布完全正常，而在连续的191例冠状动脉搭桥手术候选者中，O型血与A型血的比例失衡明显过高，这显然与流行病学数据相矛盾，流行病学数据表明A型血个体患冠心病的风险高于O型血个体。这种矛盾可以通过以下两种假设来解决：a）与O型血相比，A型血的“血栓形成倾向”导致前者冠心病患者的预后较差，从而使长期冠心病幸存者中O型血的比例过高；b）在我们71例患有隐匿性冠心病的男性中，ABO相关因素对临床前冠状动脉疾病的发展产生的独立影响微不足道。
