Grozdova M D, Grigorovich Iu A, Zubovskaia A M, Miroshnichenko V P, Sharlova I L
Vopr Med Khim. 1980 May-Jun;26(3):415-21.
A 2,3-fold increase of cAMP concentration in rabbit myocardium, increase in basal activity of adenylate cyclase and inhibition of phosphodiesterase were found in allergic impairment of heart muscle in response to repeated administration of normal horse blood serum. In presence of adrenaline and NaF the rate of adenylate cyclase activation was distinctly decreased, indicating the "desensitization" of the enzyme. At the same time, parameters of Ca2+ transport were altered; the alterations were expressed as intensification of 45Ca turnover in mitochondria and in the fraction of sarcoplasmic reticulum, as well as distinct increase in the initial rate of Ca2+ penetration into mitochondria and increase in content of calcium in the organelles.
在对家兔反复注射正常马血清导致心肌发生过敏性损伤时，发现家兔心肌中环磷酸腺苷（cAMP）浓度增加了2.3倍，腺苷酸环化酶的基础活性增强，磷酸二酯酶受到抑制。在肾上腺素和氟化钠存在的情况下，腺苷酸环化酶的激活速率明显降低，表明该酶发生了“脱敏”。与此同时，钙离子转运参数发生改变；这些改变表现为线粒体和肌浆网部分中45Ca周转的增强，以及钙离子进入线粒体的初始速率明显增加和细胞器中钙含量的增加。
