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脂质气相色谱与薄层色谱联用在功能性肝衰竭诊断中的应用

[Combination of lipid gas and thin-layer chromatography in the diagnosis of functional hepatic failure].

作者信息

Orgel' M Ia, Bondarenko B N, Sokol A S, Plenov N N, Shalimov S A

出版信息

Vopr Med Khim. 1980 Jul-Aug;26(4):548-52.

PMID:7456399
Abstract

Gas chromatography of total lipids from blood serum exhibits about 40% error in diagnosis of liver functional insufficiency. Combination of gas chromatography with quantitative thin-layer chromatography and subsequent gas chromatographic analysis of the lipid fractions obtained enabled to increase by 25% the efficiency of diagnoses not only of icteric but also of non-icteric forms of liver functional insufficiency. Simultaneous gas- thin-layer chromatographic analysis of total lipids will apparently improve the differential diagnosis of diseases accompanied by liver functional insufficiency; it permits also to study pathogenesis of impairments in lipid metabolism under conditions of liver functional insufficiency and of other pathologies.

摘要

血清总脂质的气相色谱法在肝功能不全的诊断中显示出约40%的误差。将气相色谱法与定量薄层色谱法相结合,并对所得脂质组分进行后续气相色谱分析,不仅能够将黄疸型和非黄疸型肝功能不全的诊断效率提高25%。总脂质的同时气相-薄层色谱分析显然将改善伴有肝功能不全疾病的鉴别诊断;它还允许在肝功能不全及其他病理状况下研究脂质代谢障碍的发病机制。

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