[Antitumor cytotoxins in the early stages of liver carcinogenesis].

By the cellular cytotoxic test in vitro it was demonstrated that lymphocytes of the spleen and lymphnodes from normal mice C3HA and mice given a carcinogen--o-AAT during 30 days show a cytotoxic effect on the hepatoma 22a culture. It was found that the cytotoxic activity of splenic and lymphnode lymphocytes in mice, given the carcinogen for 60 days, was reduced. In a number of experiments splenic lymphocytes of these mice were found to stimulate the hepatoma 22a cells growth in vitro.