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Biotransformation of allylbenzene analogues in vivo and in vitro through the epoxide-diol pathway.

作者信息

Delaforge M, Janiaud P, Levi P, Morizot J P

出版信息

Xenobiotica. 1980 Oct;10(10):737-44. doi: 10.3109/00498258009033801.

DOI:10.3109/00498258009033801
PMID:7456490
Abstract
  1. The epoxidation of allylbenzene, safrole, estragole, eugenol and eugenol methyl ether was investigated in rats pretreated with these compounds and also in vitro using hepatic microsomal preparations and adult rat liver cell cultures. 2. Dihydrodiols were detected in the urine and liver of rats pretreated with allylbenzene compounds. Similarly, incubation of allylbenzene epoxides with hepatic microsomal preparations and adult rat liver cell cultures gave rise to the formation of dihydrodiols.
摘要

相似文献

1
Biotransformation of allylbenzene analogues in vivo and in vitro through the epoxide-diol pathway.
Xenobiotica. 1980 Oct;10(10):737-44. doi: 10.3109/00498258009033801.
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Hydrolysis of the 2',3'-allylic epoxides of allylbenzene, estragole, eugenol, and safrole by both microsomal and cytosolic epoxide hydrolases.微粒体和胞质溶胶环氧化物水解酶对烯丙基苯、草蒿脑、丁香酚和黄樟素的2',3'-烯丙基环氧化物的水解作用。
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The side-chain epoxidation and hydroxylation of the hepatocarcinogens safrole and estragole and some related compounds by rat and mouse liver microsomes.大鼠和小鼠肝微粒体对致癌物黄樟素、草蒿脑及一些相关化合物的侧链环氧化和羟基化作用。
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Investigation of the role of the 2',3'-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs.
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The obligatory intermediacy of 16,17 alpha- and 16,17 beta-epoxides in the biotransformation of androsta-5,16-dien-3 beta-ol to androst-5-ene-3 beta, 16 alpha, 17 beta- and -3 beta, 16 beta, 17 alpha-triols by male rat liver microsomes.雄性大鼠肝微粒体将雄甾-5,16-二烯-3β-醇生物转化为雄甾-5-烯-3β,16α,17β-三醇和-3β,16β,17α-三醇过程中16,17α-和16,17β-环氧化物的必然中间体作用。
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Biochem Pharmacol. 1974 Jul 1;23(13):1845-51. doi: 10.1016/0006-2952(74)90193-2.

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