Mlczoch J, Kaindl F
Z Kardiol. 1980 Feb;69(2):126-30.
Pulmonary function has been evaluated in patients with acute uncomplicated myocardial infarction. Vital capacity,, flow-volume curves, oscillatory resistance and arterial oxygen tension have been measured within 24 hours of onset of symptoms and were repeated on day 4, 7 and 13 after infarction. In a mean interval of 6 months another measurement was done. Vital capacity was significantly reduced on the 4th day, arterial oxygen tension was also lowest on day 4, but no significant changes were seen. The expiratory flow data revealed a significant increase in the maximal expiratory flow as well as of maximal expiratory flow at 50% of the vital capacity in the second week after infarction. Oscillatory resistance was significantly increased on the first day and could be significantly reduced by inhalation of an anticholinergic broncholytic agent. These changes suggest that pulmonary function is reduced in patients with acute myocardial infarction, probably due to increase in pulmonary water and the maximal changes are present in the first week. The significant reduction of the oscillatory resistance from the first to the fourth day without significant changes of other parameters suggest an additional mechanism, which might be mediated by the vagal nerve.
已对急性非复杂性心肌梗死患者的肺功能进行了评估。在症状发作后24小时内测量了肺活量、流量-容积曲线、振荡阻力和动脉血氧张力，并在梗死后第4天、第7天和第13天重复测量。平均间隔6个月后进行了另一项测量。肺活量在第4天显著降低，动脉血氧张力在第4天也最低，但未见显著变化。呼气流量数据显示，梗死后第二周最大呼气流量以及肺活量50%时的最大呼气流量显著增加。振荡阻力在第一天显著增加，吸入抗胆碱能支气管舒张剂可使其显著降低。这些变化表明，急性心肌梗死患者的肺功能降低，可能是由于肺水增加所致，且最大变化出现在第一周。从第一天到第四天振荡阻力显著降低，而其他参数无显著变化，这提示存在一种可能由迷走神经介导的额外机制。
