Bourke R S, Kimelberg H K, Nelson L R, Barron K D, Auen E L, Popp A J, Waldman J B
Adv Neurol. 1980;28:99-109.
Most studies of clinically relevant cerebral edema emphasize the effect of added tissue fluid in white matter on gross distortion with transtentorial and subfalcine brain herniation. Our recent studies on altered tissue fluid compartmentation in cerebral gray matter suggest that significant microdistortion of relationships of capillaries to subserved tissue follows swelling of astroglia therein. Grave consequences to solute and gas exchange in focal regions may well be expected and are emphasized. The elucidation of the mechanisms of formation and inhibition of astroglial swelling by chemical agents, including chemically useful acylaryloxyacetic acid derivatives, are discussed. Furthermore, the effect of these agents in altering mortality and morbidity in a controlled, random study of animal head injury is presented.
大多数关于临床相关脑水肿的研究都强调白质中额外组织液对经天幕和大脑镰下脑疝导致的大体结构变形的影响。我们最近关于脑灰质中组织液分隔改变的研究表明，其中星形胶质细胞肿胀后，毛细血管与所供应组织的关系会发生显著的微观变形。可以预期且重点强调的是，局部区域溶质和气体交换会因此产生严重后果。本文讨论了包括化学上有用的酰芳氧基乙酸衍生物在内的化学试剂形成和抑制星形胶质细胞肿胀的机制。此外，还介绍了在一项动物头部损伤的对照随机研究中，这些试剂对改变死亡率和发病率的影响。
