Obst B E, Schemmel R A, Czajka-Narins D, Merkel R
Am J Physiol. 1981 Jan;240(1):E47-53. doi: 10.1152/ajpendo.1981.240.1.E47.
Fat depot cellularity was assessed in overfed dietary obesity resistant S 5B/Pl (S) and susceptible Osborne-Mendel (OM) rats. Cell number and lipid per cell were determined for three fat depots in both 24- and 105-day-old rats. Between these two ages, fat cell number doubled in inguinal fat depots of S rats fed high- or low-fat diets and OM rats fed a low-fat diet, but quadrupled in OM rats fed a high-fat diet. The size of adipocytes in this depot was influenced by strain but not by diet. Compared to normal weight S rats, 24-day-old overfed S rats had twice as many adipocytes in the perirenal-retroperitoneal fat depot. Overfed OM rats had 3 times perirenal-retroperitoneal fat depot. Overfed OM rats had 3 times as many. In OM rats fed the high-fat diet, there was a 16-fold increase in adipocyte number between 24 and 105 days of age. Overfeeding caused a slight increase in perirenal-retroperitoneal adipocyte size in 24-day-old rats but had little influence on cell size in 105-day-old rats.
在饮食过量的抗膳食肥胖的S 5B/Pl（S）大鼠和易患肥胖的奥斯本-孟德尔（OM）大鼠中评估脂肪储存细胞构成。测定了24日龄和105日龄大鼠三个脂肪储存部位的细胞数量和每个细胞的脂质含量。在这两个年龄之间，喂食高脂或低脂饮食的S大鼠以及喂食低脂饮食的OM大鼠腹股沟脂肪储存部位的脂肪细胞数量增加了一倍，但喂食高脂饮食的OM大鼠脂肪细胞数量增加了四倍。该储存部位脂肪细胞的大小受品系影响，但不受饮食影响。与正常体重的S大鼠相比，24日龄饮食过量的S大鼠肾周-腹膜后脂肪储存部位的脂肪细胞数量是其两倍。饮食过量的OM大鼠肾周-腹膜后脂肪储存部位的脂肪细胞数量是其三倍。在喂食高脂饮食的OM大鼠中，24至105日龄之间脂肪细胞数量增加了16倍。饮食过量使24日龄大鼠肾周-腹膜后脂肪细胞大小略有增加，但对105日龄大鼠的细胞大小影响不大。
