Hartung H J, Osswald P M, Abel J, Meissner R
Anasth Intensivther Notfallmed. 1980 Oct;15(5):392-5.
10 patients without concomitant hepatic or renal diseases were given brachial plexus block (Winnie) with etidocaine and the plasma concentrations of the drug were measured. The quantity of local anaesthetic was determined solely by the body weight and amounted to 4 mg/kg body weight. The mean peak concentration was 1.39 microgram/ml, the highest single concentration measured was 1.74 microgram/ml. Peak levels were reached within 40 minutes after administration of the local anaesthetic.
对10例无合并肝、肾疾病的患者行温妮法臂丛神经阻滞,使用依替卡因,并测定血浆药物浓度。局部麻醉药的用量仅根据体重确定,为4mg/kg体重。平均峰浓度为1.39μg/ml,测得的最高单次浓度为1.74μg/ml。局部麻醉药给药后40分钟内达到峰值水平。