Nakamura K, Koide M, Imanaga T, Ogasawara H, Takahashi M, Yoshikawa M
Anaesthesia. 1980 Dec;35(12):1202-7. doi: 10.1111/j.1365-2044.1980.tb05079.x.
This is a case report with postoperatively prolonged neuromuscular blockade of 17 hours duration suspected to be caused by trimetaphan. Inhibitory action of trimetaphan to true cholinesterase (human red cell cholinesterase) was estimated in vitro, and it is concluded that this action is too weak to cause neuromuscular disturbances by acetylcholine excess in clinical doses. Trimetaphan is considered to have a neuromuscular blocking action of a non-depolarising type.
这是一例术后神经肌肉阻滞延长达17小时的病例报告，怀疑是由曲美芬引起的。在体外评估了曲美芬对真性胆碱酯酶（人红细胞胆碱酯酶）的抑制作用，得出的结论是，该作用太弱，在临床剂量下不会因乙酰胆碱过量而引起神经肌肉紊乱。曲美芬被认为具有非去极化型神经肌肉阻滞作用。
