Bergmann H, Blauhut B, Necek S, Kramar H, Vinazzer H
Anaesthesist. 1980 Nov;29(11):623-6.
In 16 patients admitted in shock, heparin prophylaxis for DIC was carried out. The effect of heparin was monitored by a series of coagulation tests. A distinct relation was found between the effect of heparin on the aPTT and on the thrombin clotting time and the activity of antithrombin III. Even a comparatively slight diminution of this activity resulted in a considerable decrease of the heparin effect on coagulation. Since this effect is of primary importance for the efficacy of prophylaxis of DIC, regular assays of antithrombin III are proposed in shock patients receiving heparin.
对16例休克入院患者进行肝素预防弥散性血管内凝血（DIC）治疗。通过一系列凝血试验监测肝素的效果。发现肝素对活化部分凝血活酶时间（aPTT）和凝血酶凝血时间的作用与抗凝血酶III的活性之间存在明显关系。即使该活性相对轻微降低也会导致肝素对凝血的作用显著下降。由于这种作用对DIC预防效果至关重要，因此建议对接受肝素治疗的休克患者定期检测抗凝血酶III。
