Taylor M A, Abrams R
Arch Gen Psychiatry. 1981 Jan;38(1):58-61. doi: 10.1001/archpsyc.1981.01780260060006.
We categorized a sample of 134 bipolar probands into early- and late-onset groups; age 30 years was the cutting point. Early-onset probands had three times the morbidity risk /MR) for affective disorder in first-degree relatives as late-onset probands and a greater proportion of relatives with the more severe, bipolar form. Early-onset patients also exhibited more neuropsychological dysfunction, less frequently had a unipolar manic course, and had a greater MR for alcoholism in first-degree relatives. The two groups did not differ in other clinical or historical characteristics or in the proportion of EEG abnormalities. Age at illness onset is useful in clarifying the genetic basis of affective disorder. The data are consistent with a polygenic or multifactorial model of illness in which the more severe genotype is expressed earlier in life and through the course of illness.
我们将134例双相情感障碍先证者样本分为早发组和晚发组；以30岁为切点。早发先证者一级亲属患情感障碍的发病风险是晚发先证者的三倍，且患有更严重双相形式的亲属比例更高。早发患者还表现出更多的神经心理功能障碍，较少出现单相躁狂病程，且一级亲属患酒精中毒的发病风险更高。两组在其他临床或病史特征或脑电图异常比例方面无差异。发病年龄有助于阐明情感障碍的遗传基础。这些数据与一种多基因或多因素疾病模型一致，在该模型中，更严重的基因型在生命早期及病程中表达。
