早发型与晚发型双相II型障碍
Early- versus late-onset bipolar II disorder.
作者信息
Benazzi F
机构信息
Department of Psychiatry, Morgagni Public Hospital, Forlì, Italy.
出版信息
J Psychiatry Neurosci. 2000 Jan;25(1):53-7.
OBJECTIVE
To compare the clinical features and the outcome between patients with early- and late-onset bipolar II disorder.
DESIGN
Case series.
SETTING
Outpatient private practice.
PATIENTS
One hundred and seventy-nine consecutive outpatients with bipolar II disorder presenting for treatment of a major depressive episode.
OUTCOME MEASURES
Duration of illness, severity of depression, recurrences, psychosis, chronicity, atypical features and comorbidity.
RESULTS
Patients with early-onset (before 20, 25 or 30 years of age) bipolar II disorder had a significantly longer duration of illness and more recurrences compared with patients with late-onset (after 20, 25 or 30 years of age) bipolar II disorder. All other variables were not significantly different between the 2 groups.
CONCLUSIONS
Indicators of worse outcome (severity of depression, psychosis, chronicity, comorbidity) were not significantly different between patients with early- and late-onset bipolar II disorder.
目的
比较早发型和晚发型双相II型障碍患者的临床特征及预后。
设计
病例系列研究。
地点
门诊私人诊所。
患者
179例连续就诊的双相II型障碍门诊患者，均因重度抑郁发作前来治疗。
观察指标
病程、抑郁严重程度、复发情况、精神病性症状、慢性化程度、非典型特征及共病情况。
结果
早发型（20岁、25岁或30岁之前起病）双相II型障碍患者与晚发型（20岁、25岁或30岁之后起病）双相II型障碍患者相比，病程显著更长，复发次数更多。两组间的所有其他变量无显著差异。
结论
早发型和晚发型双相II型障碍患者中，预后较差的指标（抑郁严重程度、精神病性症状、慢性化程度、共病情况）无显著差异。
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