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[抗恶性肿瘤化疗中两种非特异性免疫刺激的比较]

[Comparison of two nonspecific immune stimuli in antiblastic chemotherapy].

作者信息

Bianucci P, Pastorino G

出版信息

Arch Sci Med (Torino). 1980 Jan-Mar;137(1):33-40.

PMID:7458652
Abstract

Antiblastic chemotherapy was combined with two aspecific immune stimuli, Levamisole Corynebacterium parvum, in 48 and 55 neoplastic patients respectively. C. parvum was found to be more easy to handle, particularly since Levamisole, albeit compensated by absolute lymphocytosis in many cases. In addition, C. parvum proved more effective in patients with lung and oro-pharyngeal neoplasias, whereas Levamisole appeared to be of greater use in breast cancer. Both stimuli led to improved coenaesthesia and performance status by comparison with a control group. It can thus be asserted that aspecific immunotherapy should have a place in the multidisciplinary approach currently sought.

摘要

抗有丝分裂化疗分别与两种非特异性免疫刺激剂(左旋咪唑和短小棒状杆菌)联合应用于48例和55例肿瘤患者。发现短小棒状杆菌更易于操作,特别是因为左旋咪唑在许多情况下虽有绝对淋巴细胞增多作为代偿。此外,短小棒状杆菌在肺癌和口咽癌患者中证明更有效,而左旋咪唑在乳腺癌中似乎更有用。与对照组相比,两种刺激剂均使共同感觉和身体状况得到改善。因此可以断言,非特异性免疫疗法在目前寻求的多学科治疗方法中应占有一席之地。

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