IIb型、IV型和V型高脂血症患者使用不同降脂药物治疗后脂质和脂蛋白的变化。

Changes in lipids and lipoproteins in patients with hyperlipidemia type IIb, IV and V treated with different lipid lowering drugs.

作者信息

Hutt V, Wechsler J G, Klör H U, Ditschuneit H

出版信息

Artery. 1980;8(2):113-9.

Abstract

In this study we examined the influence of different lipid lowering drugs (xantinolnicotinate (Xn), bezafibrate (Bf) and a combination of inositolnicotinate and clofibrate (In-Cl)) on the lipid and lipoprotein concentration in 61 hyperlipidemics of the types IIb, IV and V. Treatment with the 3 drugs showed a significant LDL-cholesterol decrease in type IIb and a LDL-cholesterol increase in the types IV and V. Concerning protective HDL lipoproteins an increase of HDL-cholesterol could be observed in all three types only by treatment with xantinolnicotinate and bezafibrate. Concomitantly in type V a type conversion to type IV could be observed under drug treatment regarding the chemical composition of the lipoprotein fractions VLDL, LDL and HDL.

摘要

在本研究中，我们检测了不同降脂药物（烟酸占替诺（Xn）、苯扎贝特（Bf）以及肌醇烟酸酯与氯贝丁酯的组合（In-Cl））对61例IIb型、IV型和V型高脂血症患者血脂及脂蛋白浓度的影响。用这3种药物治疗后，IIb型患者的低密度脂蛋白胆固醇（LDL-胆固醇）显著降低，IV型和V型患者的LDL-胆固醇升高。关于具有保护作用的高密度脂蛋白（HDL），仅用烟酸占替诺和苯扎贝特治疗时，所有三种类型患者的HDL-胆固醇均升高。同时，在V型患者中，就极低密度脂蛋白（VLDL）、LDL和HDL脂蛋白组分的化学组成而言，药物治疗后可观察到向IV型的类型转变。