Tye L M, Richards J F, Burton A F
Pediatr Res. 1978 Dec;12(12):1155-6. doi: 10.1203/00006450-197812000-00012.
The in vitro incorporation into mouse placenta of [14C]leucine, [3H]uridine, and [3H]thymidine fell between gestational days 14 and 19 by 61, 30 and 72%, respectively; ornithine decarboxylase activity fell by 75%. Injection of dexamethasone resulted on day 14 in values normally found between days 15 and 18. These changes coincided with rising activity in fetal liver of the enzyme 11 beta-hydroxysteroid:NADP oxidoreductase, which reduced the abundant 11-dehydrocorticosterone to the active hormone, corticosterone. These events appear to be part of a spectrum of effects produced by corticosteroids on fetal growth at this time, probably mediated primarily by fetal liver.
在妊娠第14天至19天期间，[14C]亮氨酸、[3H]尿苷和[3H]胸苷在体外掺入小鼠胎盘的量分别下降了61%、30%和72%；鸟氨酸脱羧酶活性下降了75%。在第14天注射地塞米松后，其值达到了通常在第15天至18天之间才出现的水平。这些变化与胎儿肝脏中11β-羟基类固醇：NADP氧化还原酶活性的升高相吻合，该酶将大量的11-脱氢皮质酮还原为活性激素皮质酮。这些事件似乎是皮质类固醇此时对胎儿生长产生的一系列影响的一部分，可能主要由胎儿肝脏介导。
