Fronek K, Turner J D
Atherosclerosis. 1980 Dec;37(4):521-8. doi: 10.1016/0021-9150(80)90059-3.
There is indirect evidence that sympathetic innervation may have an effect on the metabolic rate of the vessel wall. to shed some light on this question, this investigation was designed to study whether or not diminished adrenergic nerve activity in the arterial wall leads to greater susceptibility to atherosclerosis. A total of 48 rabbits was studied of which, 26 were chemically sympathectomized. Both groups of rabbits were subdivided further into a group fed regular rabbit chow and a group fed regular rabbit chow containing 1% cholesterol. Both groups, control and 6-hydroxydopamine (6-OHDA) treated, had similar plasma lipids as well as the lipid content in their aortae. After 80 days of 1% cholesterol dietary supplement the plasma lipids rose gradually with no significant difference between controls and 6-OHDA-treated animals. The aortas of sympathectomized rabbits contained significantly more cholesterol and total lipids than those from fully innervated controls. It is concluded that the the reduction of a continuous barrage of sympathetic nervous impulses to the arterial wall modifies its metabolism. In combination with additional exogenous influences, e.g. high cholesterol intake, the sympathectomized arteries become more susceptible to lipid accumulation.
有间接证据表明，交感神经支配可能对血管壁的代谢率产生影响。为了阐明这个问题，本研究旨在探讨动脉壁中肾上腺素能神经活动减弱是否会导致对动脉粥样硬化的易感性增加。总共对48只兔子进行了研究，其中26只进行了化学去交感神经处理。两组兔子进一步细分为喂食普通兔粮的组和喂食含1%胆固醇的普通兔粮的组。对照组和经6-羟基多巴胺（6-OHDA）处理的组的血浆脂质以及主动脉中的脂质含量相似。在补充1%胆固醇饮食80天后，血浆脂质逐渐升高，对照组和经6-OHDA处理的动物之间无显著差异。去交感神经处理的兔子的主动脉中胆固醇和总脂质含量明显高于完全有神经支配的对照组。得出的结论是，减少对动脉壁持续的交感神经冲动会改变其代谢。与其他外源性影响因素（如高胆固醇摄入）相结合，去交感神经处理的动脉对脂质积累更敏感。
